In a later study, Hyndman et al. (2013) analysed in vitroRET variants that had been previously reported in HSCR cases and showed that Y791F behaved similarly to the WT protein in many respects, with similar RET/pERK/pSTAT3 phosphorylation, surface localisation, and RNA and protein stability being observed. This evidence concerns the gene RET and Hirschsprung disease.