For the subjects with the BDNF Val/Met or Met/Met genotype, there was an association between the mother’s positive feelings about caring for her baby with the anxiety/depression scores on the CBCL (B = −0.59, 95% CI = −1.15 to −0.04, p = 0.035), although this association was not significant when adjusted with Bonferroni correction. This evidence concerns the gene BDNF and major depressive disorder.