Kalra et al. and Bhui et al. have demonstrated in their investigations on mouse skin tumors that bromelain treatment is associated with upregulation of p53 and Bax, activation of caspase 3 and caspase 9, attenuation of Erk and Akt phosphorylation and decrease in Bcl-2 [37,38]. This evidence concerns the gene BCL2 and skin neoplasm.