In a Danish cohort of 8,656 COPD patients, fibrinogen alone was not a strong predictor for ischemic heart disease or myocardial infarction; however, together with CRP and leukocyte count, and hazard ratios for ischemic heart disease, myocardial infarction and heart failure were approximately two-fold higher in the group with high levels of the biomarkers compared to those with low-levels [94]. The gene discussed is CRP; the disease is chronic obstructive pulmonary disease.