Analysis of CRP association with COPD severity, after adjustment for age, gender, pack-year history, presence of cardiovascular risk factors or disease and treatment with inhaled corticosteroids, showed an inverse association with 6-minute walking distance (6MWD) [88,91], diffusing capacity (adjusted for age, gender, height, smoking and BMI) [33], and hypoxemia (adjusted for sex, age, body composition and smoking) [87]. The gene discussed is CRP; the disease is chronic obstructive pulmonary disease.