It has been reported that CaMKII hyperphosphorylation of RyR2 accounts for excessive diastolic SR Ca2+ leak in non-ischemic (aortic banding) cardiomyopathy, but not in ischemia (post-MI) in which PKA phosphorylation of RyR2 is involved [24]. The gene discussed is RYR2; the disease is cardiomyopathy.