In addition, siRNA-mediated silencing of all transcripts of eight genes that showed a consistent differential splicing signature across multiple cancer types (ABCC5, ANKHD1, DYNLL1, F8, RPL31, TMEM14C, UQCC, and CRNDE) failed to reveal differences in cell viability (Figure 3C). The gene discussed is TMEM14C; the disease is cancer.