Additional recurrent mutations in SF3B1 occurred at codon 666 (K666Q and K666E) in 9% of mutant tumours (2/23), and non-recurrent mutations included G241*, N626D, A633V, Y765C, and D781E, which were found in 22% (5/23; Supplementary Table 6). Here, SF3B1 is linked to neoplasm.