When analysing the combined expression of P- and E-cadherins, two different patterns emerged: while 90% of the benign tumours preserved the expression of E-cadherin, irrespective of the P-cadherin status, 80% of the malignant tumours exhibited an overexpression of P-cadherin, independently of the E-cadherin staining pattern. The gene discussed is CDH1; the disease is cancer.