The purposes of this study were to examine the expression of P-cadherin in a series of normal mammary gland tissues and spontaneous hyperplastic and tumour mammary lesions, and to determine its relationship with the expression of E-cadherin as well as tumour clinicopathological features with recognized prognostic value [44-49], namely neoplastic intravascular emboli and lymph node metastases. The gene discussed is CDH3; the disease is neoplasm.