CDH3 and breast cancer: Although in human breast cancer P-cadherin overexpression has been associated with decreased survival and relapse-free intervals [36,64], other studies failed to find a significant association between P-cadherin and lymph node metastases at the time of diagnosis [11,21,27]; however, Gamallo et al. [26] found an association between P-cadherin expression and lymph node-positive breast tumours.