In the present study, the expression of E-cadherin was not associated to the presence of neoplastic intravascular emboli and lymph node metastases, corroborating the human breast cancer [4,9,10,72-74] and feline mammary tumours [19,31] literature in which there is no consensus regarding the prognostic value of E-cadherin. This evidence concerns the gene CDH1 and breast cancer.