In this study, we confirmed the key role of IGF-1R in SKOV3-T cells compared to SKOV3 in cell growth/proliferation, in vitro clone formation, invasion/migration, cell cycling and in vivo carcinogenic effect; then a novel anti-IGF-1R human antibody, LMAb1, was prepared and the activity was confirmed to inhibit the carcinogenesis of trastuzumab-resistant ovarian cancer cells both in vitro and in vivo. Here, IGF1R is linked to ovarian cancer.