IGF1 and neoplasm: According to the cell signaling assays shown in Figure 4F, LMAb1 could block the IGF-1 induced activation of pERK, pAKT and pIGF-1R along with the increase concentration of LMAb1, indicating that inhibition of PI3K-AKT as well as MAPK cascade might be one of the anti-tumor mechanisms of anti-IGF-1R antibody LMAb1.