IL1B and perinatal asphyxia: This result and similar recent reports on the effect of HT in term neonates with hypoxic-ischemic encephalopathy (Bednarek et al., 2012) also might suggest another possibility, that HT neuroprotection probably delayed the post-HT increase in IL-1β and caused a tendency of blunting of the late increase in MCP-1 (Figure 5).