AKT1 and neuroblastoma: In line with these results, a previous study showed that creatine increased Akt activity in C2C12 cells, a mouse myoblast cell line (Deldicque et al., 2007), and afforded neuroprotection via PI3K/Akt in the human neuroblastoma SH-SY5Y cell line (Cunha et al., 2013).