AKT1 and central nervous system cancer: For example, Chan et al. [22] reported that miR-149 could suppress breast cancer cell migration/invasion and metastasis by targeting GIT1; Cheng et al. [23] observed the decreased expression of miR-149 in clear cell renal cell carcinoma; Ke et al. [24] found that the expression of miR-149 was downregulated in lung cancer and miR-149 could inhibit EMT by targeting FOXM1; Pan et al. [18] indicated that miR-149 may play a tumor suppressive role in the proliferation and invasion of glioma cells via blockade of the AKT1 signaling.