According to the enrichment analysis on GO items and KEGG pathways, we found that the most common functions of the experimentally validated targets of candidate miRNAs targeting AKTs included focal adhesion, cell cycle, p53 signaling pathway, mTOR signaling pathway, apoptosis, VEGF signaling pathway, which cover all the hallmarks of HCC, providing a convincing evidence that these candidate miRNAs may have a definitive impact on hepatocarcinogenesis. This evidence concerns the gene TP53 and hepatocellular carcinoma.