Age, the tumor size (T1-2, T3-4), the lymph node status (N0-1, N2-3), the clinical stage, the treatment arm, RT doses, RT interruptions, CT courses, acute mucosal toxicity(1-2,3-4), VCA-IgA (Positive(≥1:80), Negative(<1:80)), EA-IgA (Positive(≥1:10), Negative(<1:10)) and the median follow-up time were not different between the 4 cumulative smoking groups, but there was a difference regarding gender (P=0.005)(Table 2). This evidence concerns the gene CD79A and neoplasm.