VEGF 1451C > T was significantly associated with RC risk (Dominant model: AOR = 1.58; 95% CI = 1.09 - 2.28; p = 0.015) whereas VEGF 1725G > A correlated with MetS risk (Dominant model: AOR = 1.61; 95% CI = 1.06 - 2.46; p = 0.026). The gene discussed is VEGFA; the disease is metabolic syndrome.