Additionally, it is well-established that the accumulation of 8-oxodG in the genome caused by inhibition of OGG1 is a key event in the pathogenesis of several human pathologies, including cancer [46], neurodegeneration [47], Parkinson's disease [48], and obesity and metabolic dysfunction [49]. This evidence concerns the gene OGG1 and obesity due to melanocortin 4 receptor deficiency.