It is possible that Nrxn2α deletions do not directly impair intellectual capacity, as the male patient with a whole gene deletion of NRXN2 had an IQ of 113, although he did have deficiencies in speech and language.13 Similarly, Nrxn1α KO mice did not show cognitive impairments in the Morris water maze.37 However, as Nrxn1α deletions have been found in mentally retarded subjects without autism,42 further work is warranted to understand the role of the neurexins in cognitive processes. This evidence concerns the gene NRXN2 and autism.