Alternately, SSOs can target regions around a mutation, such as for Duchenne muscular dystrophy (DMD), whereby frame-shift deletions in the DMD gene can be bypassed by removing additional exons to create an in-frame deletion that produces a partially functional, internally truncated dystrophin protein.7,8 It is the unique structure and function of dystrophin, with its large series of structural repeats in the central rod domain that allows this splice switching strategy to be successful.4,9,10,11,12. Here, DMD is linked to Duchenne muscular dystrophy.