Normal tissue is characterised by higher expression levels of ACTG2, VWF, EZR, B4GALNT2, CNN1, DES and MS4A12 and lower levels of NOX1, HDAC1, CCND1, LGR5, PCNA, CDX1, KRT18, NTN1, CDX2 and CASP3 when compared to adenomatous polyp or carcinoma tissues (Figure 1). The gene discussed is CDX2; the disease is carcinoma.