PLX4720 reduced the effect of PD0325901 in NRAS-mutated melanoma cells (Fig. 2A), whereas the RAF/MEK inhibitor CH5126766 markedly inhibited the colony formation with inhibition of the RAF-MEK pathway even in NRAS-mutated melanoma cells (Fig. 1E, Fig. 2A). This evidence concerns the gene MAP2K7 and melanoma.