The mechanism by which Mcl-1 blocks the progression of apoptosis is through binding and sequestering the pro-apoptotic BH3-only proteins Bim, PUMA, Noxa, Bak, and Bax [4], preventing pore formation on mitochondrial membrane of MM cells and the release of cytochrome c into the cytoplasm. This evidence concerns the gene MCL1 and Miyoshi myopathy.