Medullary ERα protein expression (B) was affected by neither hypercholesterolemia nor ovariectomy (C57 Sham: 1.00 ± 0.04; C57 OVX: 1.03 ± 0.02; ApoE Sham: 0.95 ± 0.06; ApoE OVX: 1.00 ± 0.03 au). The gene discussed is APOE; the disease is familial hypercholesterolemia.