Concomitant SAHA, BZ, and CAM treatment markedly enhanced CHOP induction via ER stress loading in MM cells (Fig. 7A), whereas a CHOP−/− MEF cell line nearly completely cancelled the pronounced cytotoxicity in response to the SAHA/BZ/CAM combination treatment (Fig. 7C). Here, DDIT3 is linked to Miyoshi myopathy.