Besides defective memory/learning and impaired eye vision abilities, RasGrf1 KO mice also exhibit a reduced body size linked to a “pancreatic” phenotype that includes significantly reduced number and size of pancreatic islets, diminished beta cell proliferation and neogenesis, and associated hypoinsulinemia and glucose intolerance, suggesting an essential role of RasGrf1 in beta cell development and function. Here, RASGRF1 is linked to Hypoinsulinemia.