The second polymorphism found to affect survival of patients with multiple myeloma was rs11077 in XPO5. This miRSNP, apart from its potential impact on expression of XPO5, can also affect the whole miRNA-ome of the cell as XPO5 encodes for exportin-5, which is required for the export of precursor miRNAs from nucleus to cytoplasm where they are subject to further steps of maturation [17]. This evidence concerns the gene XPO5 and AL amyloidosis.