In logistic regression analysis using the genotype of the MLH1-93G/A SNP (A/A vs. A/G + G/G), tumor location (right vs. left), gender (female vs. male) and age at onset (more than 70 vs. less than 70) as the independent variables, genotype was shown to be the most significant risk factor for hypermethylation of the MLH1 promoter region (Table 3). This evidence concerns the gene MLH1 and neoplasm.