Consistently with the lower polη amount, TLS across a TT CPD was lower (two-tailed t-test, P value <0.003), and more mutagenic (χ2-test, P value <0.01) in the NPM1c+ AML cells compared with the NPM1wt AML cells (Fig. 6c). This evidence concerns the gene POLH and acute myeloid leukemia.