TGFB1 and renal fibrosis: Three miRNA families, miR-21, miR-200 and miR-29, are regulated by TGF-β and have been shown to modulate renal fibrosis either by amplifying TGF-β signaling and promoting fibrosis (miR-21) or by inhibiting EMT and reducing fibrosis (miR-29 and miR-200) (20–22).