INS and type 2 diabetes mellitus: Recently, using genome-wide complex trait analysis, the genome-environment contribution of 14 dietary factors (glycemic load, total energy, protein, total fat, SFA, MUFA, PUFA, n-3 PUFA, n-6 PUFA, n-3:n-6 PUFA, carbohydrate, alcohol intake, trans fat and fiber) to the total phenotypic variance of 4 T2DM-related traits (fasting glucose, fasting insulin, HOMA-IR and HOMA of β cell function) were analyzed [83].