Bilberry anthocyanins improved hyperglycemia and insulin sensitivity in T2DM mice by downregulating the expression of gluconeogenic enzymes, upregulating the expression of Pparα, L-Cpt-1, Glut4 and aconitase (Aco) in the livers of bilberry-supplemented T2DM mice, as well as upregulating the expression of Glut4 in the white adipose tissue (WAT) of bilberry-supplemented T2DM mice [92]. The gene discussed is PPARA; the disease is type 2 diabetes mellitus.