It has previously been shown that the risk of hypoglycaemia in people with insulin-treated T2DM increases with increasing diabetes duration [8], and Henderson et al. [22] reported that NSHE frequency among people with T2DM only reaches the same level as in people with T1DM after 10 years of insulin use in T2DM [22]. The gene discussed is INS; the disease is type 2 diabetes mellitus.