HMGA2 and ataxia telangiectasia: To find new potential therapeutic targets for the treatment of AT/RT, Zhang et al. [7] have recently searched for novel genomic aberrations by investigating the copy number and expression alterations of let-7a3/let-7b miRNA and correlated them with expression of high-mobility group AT-hook 2 (HMGA2) oncoprotein, a target of let-7 miRNA family, in 18 AT/RT samples.