We confirmed the previously reported proliferative effect of HMGB1 on human pulmonary artery smooth muscle cells in Figure 7D. Considering its potential effects on endothelium hyperactivity and pulmonary vascular remodeling, it is reasonable to envision a valuable role for HMGB1 in the pathophysiology of pulmonary hypertension. The gene discussed is HMGB1; the disease is pulmonary arterial hypertension.