EGFR and glioblastoma: We found that, while a high level of EGFR amplification was observed in around half of the glioblastoma patients from the TCGA cohort, PHD3 suppression through deletion and/or promoter methylation was much more common in the tumors without EGFR amplification: over 70% of the patients with PHD3 deletion and/or promoter methylation did not have an EGFR amplification, while over 80% of the patients with an EGFR amplification did not harbour a PHD3 deletion and/or promoter methylation (Fig. 6d,e).