With regard to the relationship between N1IC and clinicopathological parameters, we found that high expression of N1IC was significantly related to lymph node metastasis, which is in agreement with our previous studies focusing on Notch1, meanwhile, over-expression of Notch1 was positively correlated with invasion and metastasis by epithelial-mesenchymal transition (data not shown). Here, NOTCH1 is linked to metastatic malignant neoplasm in the lymph nodes.