Further, we analyzed these results and found it was the interesting that 25 out of 28 SIRT1 low expression cancers were N1IC high expression, combining with shorter OS and DFS in SIRT1-low/N1IC-high group than in low SIRT1 alone, so the finding raised the intriguing possibility that inhibition of N1IC in low SIRT1 breast tumors might improve the survival of patients. Here, SIRT1 is linked to breast neoplasm.