SIRT1 and cancer: Further, we analyzed these results and found it was the interesting that 25 out of 28 SIRT1 low expression cancers were N1IC high expression, combining with shorter OS and DFS in SIRT1-low/N1IC-high group than in low SIRT1 alone, so the finding raised the intriguing possibility that inhibition of N1IC in low SIRT1 breast tumors might improve the survival of patients.