Recent studies of the prognostic role of SIRT1 in breast cancer have reported contradictory results [8-12], and previous studies concerning the role of Notch1 signaling in breast carcinoma have reported that expression of Notch1 is related to poor survival [21,22], but to date, no direct assessment of the correlation between SIRT1 expression, Notch1 signaling, and patient outcome has been carried out. The gene discussed is SIRT1; the disease is breast cancer.