AKR1C3 and neoplasm: Immunohistochemical staining analyses indicated that 7 (35%) of the radioresistant tumor specimens displayed high levels (+++, i.e.>75% tumor cells are AKR1C3 positive), and 8 (40%) displayed intermediate levels of AKR1C3 expression (++, i.e. 75%∼50% tumor cells contains AKR1C3 protein) (Fig. 5A–B and Fig. S4 in File S1).