In eight dura mater graft associated CJD (dCJD) cases, Satoh et al. reported a C-terminal PrP fragment of 11–12 kDa termed fPrP11-12, a fragment that could be equivalent to or be the same as the PrP-CTF12 identified by our studies [ref 23 and the current study] and that was detected only in three cases without PrP plaques (np-dCJD) but not in other five cases with PrP plaques (p-dCJD) [24]. Here, PRNP is linked to Creutzfeldt Jacob disease.