13 Manekeller Manekeller S S Sauerbruch Sauerbruch T T Fischer Fischer HP HP Propping Propping P P Hirner Hirner A A Heterozygous alpha-1-antitrypsin deficiency (PiMZ): risk factor in the development of primary liver carcinoma in non-cirrhotic liver Heterozygous alpha-1-antitrypsin deficiency (PiMZ): risk factor in the development of primary liver carcinoma in non-cirrhotic liver Z Gastroenterol. The gene discussed is PSMA6; the disease is carcinoma of liver and intrahepatic biliary tract.