Firstly, for four diseases, we observed enrichment of differentially expressed lncRNAs between those in the disease loci and all Gencode lncRNAs (α < 0.005) in three circulating immune cell types (NK cells for IBD, JIA, PBC, PS; memory and CD8+ T cells for JIA, PBC, PS, RA; Figure S6A in Additional file 11). This evidence concerns the gene CD8A and primary biliary cholangitis.