SMAD3 and cancer: For modules M3, M4, and M5, although the corresponding GO_BP terms were not directly related to cancer, we found PrCa-relevant genes in these three modules, including BTG2[72], FOS (also known as c-Fos) [73], and CXCR4[74] in module M3; ARFGAP3[75] and CDH1[76] in module M4; and SMAD3[77] and MXI1[78] in module M5.