There were no cohort effects on the CSF levels of novel SNAP-25 biomarkers, P-tau181 or Aβ1-42 (data not shown), allowing statistical analyses of the entire group of participant samples from Alzheimer’s disease (N = 36) and controls (N = 32) (Figure 3J-L). The gene discussed is SNAP25; the disease is early-onset autosomal dominant Alzheimer disease.