MTDH is intensively expressed in many types of cancer, including hepatocellular carcinoma (HCC), breast, prostate, gastric, renal and colorectal cancer, non-small cell lung cancer, esophageal squamous cell carcinoma and glioma, actively participating in cancer invasion, angiogenesis, autophagy and metastasis formation [13–17]. Here, MTDH is linked to hepatocellular carcinoma.