MTDH is intensively expressed in many types of cancer, including hepatocellular carcinoma (HCC), breast, prostate, gastric, renal and colorectal cancer, non-small cell lung cancer, esophageal squamous cell carcinoma and glioma, actively participating in cancer invasion, angiogenesis, autophagy and metastasis formation [13–17]. The gene discussed is MTDH; the disease is cancer.