ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: Although the BCR-ABL oncoprotein, a hallmark of CML, constitutively activates multiple signaling pathways [3], our group was particular interested in STAT3 signaling activation, as the constitutive activation of STAT3 is associated with oncogenic transformation induced by the viral Src oncoprotein [2].