NEAT1 and breast cancer: A recent pangenomic analysis of hypoxic gene regulation, in MCF-7 breast cancer cells, identified NEAT1 as one of the most hypoxia-upregulated lncRNAs.5 Closer inspection of these data indicated that both the 3.7-kb poly-adenylated NEAT1-1 and the 23-kb non-adenylated NEAT1-2 are upregulated by hypoxia (Figure 1a).