A wealth of studies have reported that the COL11A1 human gene, coding for the α1 chain of procollagen and mature collagen of type XI, which is an extracellular minor fibrillar collagen, is up-regulated in some human tumours and in mesenchymal-derived tumour cell lines [1–32], as well as in mesenchymal stem cells and osteoblasts [33–35]. Here, COL11A1 is linked to neoplasm.