ErbB2 and pErbB2 were nearly absent in glandular epithelial cells of colorectal mucosa adjoining cancer tissue.ErbB3 immunoreactivity was predominantly observed in the cytoplasm and membrane of cancer cells in 64 (41%) cases (Figure 2H), whereas pErbB3 immunoreactivity was exclusively observed in the nuclei of cancer cells in 40 (26%) cases (Figure 2I). This evidence concerns the gene ERBB3 and cancer.