To block Notch signaling during pancreatic carcinogenesis, we crossed a mouse model of pancreatic cancer, based on pancreas-specific expression of mutant Kras (p48-Cre; LSL-KrasG12D; hereby referred to as KC) with a transgene expressing a Dominant-Negative form of Mastermind-like1 (DNMAML), which encodes for a truncated form of MAML1 (aa 13–74) fused to GFP, downstream of a LoxP-flanked stop cassette [5, 6, 21] (Figure 1D). This evidence concerns the gene MAML1 and familial pancreatic carcinoma.