To better control the potential stromal contamination in CAH, we explored the validation cohort by immunohistochemical (IHC) protein staining of the epithelial component for the oncoprotein Stathmin, suggested as a surrogate marker for PI3K and PTEN dysregulation in endometrial and breast cancers [16, 19]. Here, PIK3CA is linked to congenital adrenal hyperplasia.