Intriguingly, metformin, an anti-diabetic drug used to treat metabolic syndrome and obesity related diabetes, has been shown to inhibit cell proliferation in endometrial cancer cells with activated KRAS, further suggesting a link between KRAS status and the potential for targeting metabolic syndrome in obese patients with endometrial carcinoma (precursor) lesions [31]. The gene discussed is KRAS; the disease is endometrial carcinoma.