Thus, increased expression of IP-10 in pancreatic cancer tissue, although would lead to recruitment of CXCR3+ Tregs and CXCR3+ CD4+ and CD8+ T cells as shown in our in vitro assay, may preferentially contribute to increased infiltration of Tregs in the tumor due to the elevated numbers of circulating Tregs, hence inhibiting tumor immunoresponse. This evidence concerns the gene CD8A and pancreatic neoplasm.