LCLAT1 and hypothyroidism: In support of the regulatory role of ALCAT1/AGPAT8 in CL remodeling in response to oxidative stress, the expression of ALCAT1 in the liver and heart was significantly down-regulated in mice with hypothyroidism and up-regulated in mice treated with thyroid hormone, which is known to stimulate mitochondrial activity, oxidative stress, and CL remodeling.