In contrast, RUNX2 mainly exhibits oncogenicroles in breast cancer by promoting invasiveness and metastasis via its target,SNAI2 (Chimge et al.,2011); however it may also play a tumor suppressor role in breast cancer byantagonizing ERα (thus, similar to RUNX3) (Chimge et al., 2012). This evidence concerns the gene RUNX3 and neoplasm.