AQP1 and xerostomia: Our group is developing a nonviral approach to attempt to mimic positive reports of therapeutic efficacy in a human clinical trial utilizing adenovirus-mediated gene transfer of aquaporin-1 to the salivary glands of humans suffering from radiation-induced xerostomia.24,25 In this effort, the translational relevance of these findings should be directly relevant to the design of nonviral vectors for salivary gland gene therapy.