HSV-2/β g co-infection decreased EB production compared to CtE infection alone, in the presence of DMSO, PBS or Akt, PI3K, JAK, or JNK inhibitors, indicating the inhibitors did not reverse the HSV co-infection-induced reduction in infectious EB production (Figures 2A,B). The gene discussed is MAPK8; the disease is epidermolysis bullosa.